On my relatively slow system at work, Google Reader often was very lame when having been loaded in one of a few browser tabs. A few weeks ago I decided to try out Prism.
For me, the reader became remarkably faster while working in a Prism window than in a browser tab.
Actually, I'm using a whole bunch of Google services and now split out all of them via Prism. Then I made command line shortwords to use in SlickRun. Now I'm able to start my web applications by hitting WinKey-Q (shortcut to jump into slickrun's entry line), then typing Gmail(+Enter), Greader, Gnotes and so on. The applications load faster, work faster (at least on my system) - and I can switch easily between them by using Alt-TAB.